Looking back, and looking forward.
Crowdsourced games and competitions fill an important niche
Simulations can teach us how young bodies and faces develop; how an artery compensates for decades of fatty plaque deposits by growing and thickening its walls; how tissue engineers can best coax endothelial cells to develop into organized sheets of skin for burn patients; and how cancerous tumors invade neighboring tissue.
Several big-dollar initiatives received NIH funding in late 2010
Either/or molecular circuitry modeled
Describing information flow within cells
Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.
Network biology is allowing scientists to convert their cellular parts lists into insights about complex diseases