By computationally combining incomplete imaging information with bits and pieces of structural data from all sorts of different experiments, researchers have worked out the protein-by-protein structure of an important cellular assembly called the nuclear pore complex.
Central repository of information on genes and proteins requires participation by the scientific community
Models of healthy and diseased lipid profiles could prove valuable diagnostically.
Using Rosetta@Home, a program that runs on the personal computers of 150,000 volunteers worldwide, David Baker’s team predicted the structure of a 112-amino-acid protein from scratch.
Predicting protein localization
Researchers now have a tool for imaging the structures of biological molecules—and they are reaping the benefits big time.
Knot-detecting algorithm discovers that proteins are rarely knotted
i2b2 enables the use of existing clinical data for discovery research
A combination of genomics data and molecular dynamics modeling is sufficient to predict protein complex structure
A model of chromatin explores how it folds and unfolds
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