Upcoming biocomputing conferences
The 6th Annual International Conference on Computational Systems Bioinformatics (CSB2007) coordinated by the Life Sciences Society.
WHAT: This conference is designed for any scientist interested in...
Jul, 01, 2007
Computational modeling can help fill gaps in how we develop and review new drugs and devices
What role does computational modeling play at the United States Food and Drug Administration (FDA)? If you ask Paul Watkins, MD, director of the Hamner—University of North Carolina...
Sep, 01, 2011
Decades of steady progress in pharmacogenetics have unearthed hundreds of associations between genes and drug response. But the field has to solve some theoretical and practical issues before it can deliver on the promise of personalized drug therapy.
As algorithms go, it’s deceptively simple. Just add together eight weighted pieces of patient information—age, height, weight, race, data about two genes, and a pair of clinical...
Jul, 01, 2009
From cellular responses to drugs, to adverse effects and drug repositioning, systems pharmacology gets the BD2K treatment
Relevant NIH Institutes:NCI, NHLBI, NIDDK, NINDS and all other disease-focused Institutes
The Big Data era in biomedicine offers a grand promise: that by crunching vast quantities of multi-...
Jun, 13, 2017
Cardiovascular models are moving to the bedside
Pacemakers, heart-lung machines, stents and artificial hearts all sprang from successful partnerships between engineers and doctors. “From its inception in the 1950s, heart surgery has...
Mar, 01, 2014
i2b2 enables the use of existing clinical data for discovery research
In 2011, the FDA issued a black box warning on Celexa, one of the most widely prescribed antidepressants in the US. At higher doses, the drug had been linked to potentially dangerous changes in the...
Mar, 01, 2014
Computers and human experts duke it out over who is better at diagnosing disease, interpreting images, or predicting protein structure
Dorothy Rosenthal tenses over her microscope, peering at the problematic nucleus on the Pap smear yet again. “It’s abnormal,” she decides, and then hesitates. “No, it’s...
Jul, 01, 2006
Bringing models closer to reality
When the ill-fated space shuttle Columbia launched on January 16, 2003, a large piece of foam fell off and hit the left wing. Alerted of the impact, NASA engineers used a computer model to predict...
Oct, 19, 2012
Computation can speed up the time it takes to find new binding partners for old drugs
When cheap drugs are needed fast, researchers and drug companies are increasingly turning to an interesting short-cut: repurposing existing drugs for new uses. Because drugs exert multiple actions in...
Apr, 01, 2011
Computation offers a window into a disease often described as a black box
The growing threats of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB) are spurring worldwide interest in faster and more innovative research approaches, such as...
Jun, 06, 2012
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